Overview
| Description |
CD158, also known as KIRs (Killer Cell Immunoglobulin Like Receptors), are a transmembrane protein family classified based on the number of extracellular immunoglobulin domains (2D or 3D) and whether they have long (L) or short (S) cytoplasmic domains. Having two (KIR2D) or three (KIR3D) Ig like extracellular domains. CD158 is mainly expressed on NK cell subsets and a small number of CD8+T cells. HLA-C is a ligand for CD1588/h.
Mouse monoclonal antibody 4AHP-MA4 recognizes the extracellular epitopes of CD158 isoforms KIR2DL1 (CD158a), KIR2DS5 (CD158g), KIR2 DS1 (CD158 h), and KIR2DS3. It does not recognize CD158b1, d, f, i, j subtypes.
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| Related Protocol |
Cell Surface Flow Cytometry Staining Protocol
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| REFERENCES |
1.Krakow S, et al. 2019. Front Immunol. 10:1484.
2.Gabaev I, et al. 2020. Cell Rep. 33:108249.
3.Celis‐Gutierrez J et al. 2019. Cell Rep. 27(11):3315-3330 .
4.Chevrier S, et al. 2018. Cell Syst. 0.675.
5.Kim MH, et al. 2018. Cancer Immunol Res. 0.427083333.
6.Muthumani K, et al. 2012. J Immunol. 187:2932.
7.Hobo W, et al. 2010. Blood 25:4501. (FC)
8.Alvarez IB, et al. 2010. J. Infect. Dis. 202:524. (Block)
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